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The PIONEER program tested oral semaglutide the first GLP-1 receptor agonist available as a pill rather than injection. Across multiple PIONEER trials in T2DM, oral semaglutide produced HbA1c and weight reductions

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Among patients with moderate hypertriglyceridemia and high cardiovascular risk, monthly olezarsen injections resulted in significantly greater reduction in triglyceride levels at 6 months than placebo. Full EssenceTIMI 73b phase 3 trial results

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